Metronidazole co-crystals - Paperback

by Farida Allal (Author), Fatima Zohra Helifa (Author), Khadidja Lamri (Author)

Strategies commonly used to improve the therapeutic effect and antibacterial activity of active pharmaceutical ingredients involve exploring their solid forms, notably polymorphs, solvates/hydrates, salts and cocrystals. Among the various approaches considered to remedy the problem of bacterial resistance, the strategy of co-crystallization of antibiotics with coformers appears to be a promising solution for improving physicochemical properties, inhibiting resistance and enhancing antibacterial activity.