{"product_id":"developmental-oncology-principles-and-therapy-of-cancers-of-children-and-young-adults-hardcover","title":"Developmental Oncology: Principles and Therapy of Cancers of Children and Young Adults - Hardcover","description":"\u003cdiv\u003e\u003cp style=\"text-align: right;\"\u003e\u003ca href=\"https:\/\/reportcopyrightinfringement.com\/\" target=\"_blank\" rel=\"nofollow\"\u003e\u003cb\u003eReport copyright infringement\u003c\/b\u003e\u003c\/a\u003e\u003c\/p\u003e\u003c\/div\u003e\u003cp\u003eby \u003cb\u003eAlex Kentsis\u003c\/b\u003e (Author), \u003cb\u003eAlejandro Gutierrez\u003c\/b\u003e (Author)\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eA variety of cancers\u003cbr\u003e affect children and young adults, including leukemias, sarcomas, and \u003cbr\u003etumors of the nervous system. These are caused by errors that occur \u003cbr\u003eduring development and arise in specific populations of cells that \u003cbr\u003eaccumulate somatic mutations in early life.\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e \u003cp\u003eWritten and edited by experts in the field, this collection from \u003cem\u003eCold Spring Harbor Perspectives in Medicine\u003c\/em\u003e\u003cbr\u003e provides a comprehensive review of our understanding of cancers that \u003cbr\u003eoccur during childhood and in young adults, the mechanisms underlying \u003cbr\u003etheir appearance, and current and future treatment strategies. Recent \u003cbr\u003ediscoveries show these young-onset cancers are fundamentally \u003cbr\u003edevelopmental in origin. The contributors review how developmental \u003cbr\u003eprocesses in the growing body generate cell states that are susceptible \u003cbr\u003eto tumorigenesis in particular types of cells. They discuss the bases \u003cbr\u003efor genetic predisposition, endogenous and exogenous somatic mutational \u003cbr\u003eprocesses, epigenetic regulation, and the influence of the immune and \u003cbr\u003etissue microenvironments.\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e \u003cp\u003eIn addition, the authors examine the \u003cbr\u003emultiple therapeutic approaches used to target young-onset cancers, such\u003cbr\u003e as combination treatments and immunologic, metabolic, and cellular \u003cbr\u003etherapies. Cancer surveillance is also covered, as well as the unique \u003cbr\u003echallenges of pediatric cancer drug development. The volume will \u003cbr\u003etherefore be an essential reference for cancer biologists, practicing \u003cbr\u003eoncologists, and those interested in how we can drive progress in cancer\u003cbr\u003e treatment.\u003c\/p\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003eNumber of Pages:\u003c\/strong\u003e 300\u003c\/div\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003eDimensions:\u003c\/strong\u003e 0.75 x 10 x 7 IN\u003c\/div\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003ePublication Date:\u003c\/strong\u003e March 26, 2025\u003c\/div\u003e\n            ","brand":"BooksCloud","offers":[{"title":"Default Title","offer_id":52241393778962,"sku":"9781621825050","price":135.09,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0941\/2211\/5346\/files\/jpiy4687eo9781621825050.webp?v=1782760327","url":"https:\/\/ckbookstore.net\/products\/developmental-oncology-principles-and-therapy-of-cancers-of-children-and-young-adults-hardcover","provider":"CK BOOKSTORE","version":"1.0","type":"link"}